CORDIS Project
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This project explores how Human Papillomavirus Type 16 manipulates cellular processes during infection. It focuses on the virus's interaction with the mitotic machinery of host cells, aiming to uncover mechanisms that may lead to cancer development.
Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia.
Due to this complexity, how HPV16 infects cells is an understudied field of research.
Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery.
Our findings indic…
UNIVERSITAET MUENSTER
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