CORDIS Project
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This project focuses on MKlp2, a protein involved in cell division, particularly during mitosis. It aims to explore its interactions and mechanisms to understand its potential as a target for cancer treatment.
Mklp2, a mitotic kinesin and a prime target for cancer therapyMKlp2 belongs to kinesin 6 family and was first identified as an effector protein of small G protein Rab6A, involving in the retrograde transport between Golgi and ER.
While its function in Golgi-ER trafficking awaits further study, MKlp2 has been shown to play crucial role in mitosis.
It is essential to relocate chromosomal passenger protein Aurora B and the mitotic regulator Plk1 to the central spindle during anaphase.
Depletion of…
INSTITUT CURIE
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