CORDIS Project
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This project focuses on developing a system for analyzing membrane proteins in their native cellular environment, aiming to enhance understanding of drug interactions and mechanisms. By producing these proteins in relevant cell systems, the project seeks to facilitate the determination of their 3D structures in complex…
More than two-thirds of all described drug targets are membrane proteins, but only for a small fraction of these hydrophobic proteins the structure is currently known.
Membrane proteins are inherently challenging to produce and analyze.
Consequently, in pre-clinical investigations their mechanism and drug interactions are often only derived from purified truncated parts of these proteins, taken out of their native biological context.
Lacking the effects of surrounding membrane components, conclu…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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