CORDIS Project
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This research focuses on the self-renewal mechanisms of mouse embryonic stem cells, investigating how different signaling pathways contribute to maintaining their pluripotency. It aims to identify novel genes involved in these processes through advanced molecular techniques.
Over the past few years, a view has emerged that pluripotency in mouse embryonic stem cells (ESCs) is cell-autonomous and does not depend on external signals.
This was based on work that showed that a combination of a small molecule ERK inhibitor with a GSK3 kinase inhibitor was sufficient to maintain self-renewal, in absence of any growth factors. I have now discovered that autocrine or paracrine signalling via the Wnt pathway plays an essential role in ESC self-renewal, and is required to inhi…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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