CORDIS Project
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This project investigates the gene regulatory network of nuclear receptors in microglial cells, aiming to understand their expression in response to neurotoxic stimuli. By identifying key transcription factors and their interactions, the research seeks to model how to enhance the protective functions of microglia while…
Nuclear receptors (NR) constitute a large transcription factor (TF) family with ~50 NRs identified in human or mouse. NRs have crucial roles in multiple tissues and biological processes.
Consequently, misregulation of NR gene expression has been linked to several severe pathologies including cancer and neurodegenerative diseases.
Despite their pathological importance, the core NR gene regulatory network (i.e. the protein-DNA interactions or PDIs controlling the expression of NR genes) has been v…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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