CORDIS Project
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This project investigates the role of the Cockayne syndrome complementation group A protein in DNA repair mechanisms. By employing a structure-driven proteomic approach, it aims to elucidate how this protein interacts with the DDB1-CSA-Cul4-Rbx1 ubiquitin ligase complex to facilitate the repair of damaged DNA.
Cockayne syndrome is a congenital disease with impaired DNA repair in actively transcribed genes.
Affected children show developmental abnormalities and signs of premature aging.
Cockayne syndrome is caused by mutations in the Cockayne syndrome complementation group A (CSA) and B (CSB) genes.
While CSB encodes a SWI/SNF ATPase that likely assists the stalled RNA polymerase in overcoming lesions, CSA’s detailed role in repair has so far remained elusive. CSA is part of the DDB1-CSA-Cul4-Rbx1 E3 u…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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