CORDIS Project
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This project investigates the role of Wnt11 in the differentiation of lung epithelial cells and stem cells involved in lung repair. It utilizes a 3D lung tissue model to study how Wnt11 may prevent harmful cell transitions and promote healing in damaged lung tissue.
Acute and chronic lung injury is a major cause of morbidity and mortality worldwide.
During physiological repair of the damaged alveolar epithelium transdifferentiation of Alveolar Type II (ATII) cells occurs into Alveolar Type I (ATI) cells.
Also, recently identified human multipotent lung stem cells (hLSCs) may participate in repair mechanisms of injured lung tissue by differentiating into multiple cell lineages in the lung.
In pathological repair mechanisms, epithelial-mesenchymal transition…
THE UNIVERSITY OF BIRMINGHAM
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