CORDIS Project
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ModularBioMachine aims to enhance understanding of Complex I, a key enzyme in cellular metabolism, and its similarities with microbial hydrogenases. By combining structural biology and functional analysis, the project seeks to uncover the mechanisms of energy conversion in these biomachines, which are vital for both hu…
Complex
I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the mammalian cell, uses the reducing potential of NADH to drive protons across the inner mitochondrial membrane and power ATP synthesis.
It is a keystone of metabolism, crucial for survival of human cells, and a primary site of mitochondrial dysfunctions and clinical disease.
Complex I is also an efficient energy-converting biomachine, which shares conserved subunits, a molecular architecture, and modular d…
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