CORDIS Project
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This project investigates the role of local interneurons in the spinal cord that regulate muscle activation during movement. It focuses on understanding the cholinergic signaling pathways and their impact on motor neuron activity, using various experimental techniques to explore the modulation of locomotion.
The executive component of movement – the task of determining which muscles to activate, how intensely, and for how long – depends on neural circuits located in the spinal cord.
At the core of these circuits are local interneurons (INTs) that regulate the pattern and frequency of motor neuron (MN) firing.
Spinal motor activity is shaped by a combination of amino acid mediated excitation and inhibition, but the amplitude of motor bursts depends in large part on modulatory systems. I have identifi…
BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
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