CORDIS Project
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This project investigates the structure and function of 14-3-3 proteins, which play critical roles in cell regulation and disease. By determining the molecular structure of these proteins in complex with their targets, the research aims to enhance understanding of their regulatory mechanisms.
14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression.
They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 850 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active conformations in their target proteins.
To date, no crystal structure is known for a 14-3-3 dimer in c…
Masarykova univerzita
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