CORDIS Project
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This project investigates the mechanics of epithelial monolayers, which are crucial for tissue development and function. By developing a new technique for studying these tissues under controlled conditions, the research aims to uncover how molecular structures influence mechanical properties and cellular behaviors duri…
Epithelial monolayers are amongst the simplest tissues in the body, yet they play fundamental roles in adult organisms where they separate the internal environment from the external environment and in development when the intrinsic forces generated by cells within the monolayer drive tissue morphogenesis.
The mechanics of these simple tissues is dictated by the cytoskeletal and adhesive proteins that interface the constituent cells into a tissue-scale mechanical syncitium.
Mutations in these pro…
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