CORDIS Project
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This project investigates the molecular changes in the brain's reward circuitry caused by chronic cocaine exposure. It aims to identify gene regulatory networks that contribute to addiction, focusing on specific genes and their roles in synaptic function and behavior.
Drug addiction is a maladaptive form of experience-dependent plasticity that develops following chronic exposure to drugs of abuse.
Drug experience induces plasticity of synaptic transmission within the neural circuitry of reward, which is thought to depend upon modulation of gene expression.
Preliminary data I acquired demonstrates that chronic exposure to cocaine results in dramatic rewiring of gene regulatory networks within the nucleus accumbens, a key component of the brains’ reward circuit…
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