CORDIS Project
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This research investigates the mechanisms by which phagocytes recognize and eliminate dying cells using the Drosophila model. It aims to clarify the role of a novel receptor, Six Microns Under, in the phagocytosis process, contributing to our understanding of cell clearance and its implications for inflammation and aut…
The proper elimination of unwanted or aberrant cells through apoptosis and subsequent phagocytosis plays a crucial role in metazoan development and tissue homeostasis.
Inefficient or defective removal of apoptotic cells leads to inflammation and autoimmune diseases.
Given that in vertebrates phagocytosis is a complex and highly redundant process, we are using the Drosophila model, which permits comprehensive in vivo studies and provides complement to medical and applied approaches in the field.…
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