CORDIS Project
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This project aims to understand how the innate immune system recognizes foreign nucleic acids, focusing on the DAI protein's role in detecting double-stranded DNA. The research will clarify the molecular interactions involved, contributing to knowledge about immune responses and potential autoimmune disorders.
The innate immunity system for vertebrates represents the front-end of their defense against invading viruses and bacteria.
Its activation is based on the recognition of pathogen associated molecular patterns (PAMPs) by specialized receptors.
Central in the pathogen recognition process is the detection of nucleic acids.
However, how exactly foreign nucleic acids are distinguished from host DNA and RNA is poorly understood and of great importance since false recognition leads to severe auto-immun…
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