CORDIS Project
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This research investigates alternative electron transport pathways in cells to alleviate metabolic stress caused by mitochondrial dysfunction. By engineering specific enzymes, the project aims to reduce oxidative stress and improve cellular health in various models.
Many eukaryotes, but not the higher metazoans such as vertebrates or arthropods, possess intrinsic by-pass systems that provide alternative routes for electron flow from NADH to oxygen.
Whereas the standard mitochondrial OXPHOS system couples electron transport to proton pumping across the inner mitochondrial membrane, creating the proton gradient which is used to drive ATP synthesis and other energy-requiring processes, the by-pass enzymes are non-proton-pumping, and their activity is redox-reg…
TAMPEREEN YLIOPISTO
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Finland, HELSINGIN YLIOPISTO
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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