CORDIS Project
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This project aims to explore the role of specific modifications of Liver X Receptors in cholesterol metabolism. By investigating how acetylation and phosphorylation affect these receptors, the research seeks to develop new therapies for metabolic diseases.
Liver X receptors (LXRs) alpha (a) and beta are nuclear receptors that act as metabolic sensors for cellular cholesterol. LXR agonists increase HDL cholesterol levels, have anti-inflammatory properties and improve insulin sensitivity.
Therefore LXRs are now considered promising drug development targets for the management of human metabolic diseases.
The search for LXR ligands void of their deleterious hyper-triglyceridemic actions has been traditionally based on their effects on receptor binding…
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