CORDIS Project
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This project aims to explore the mechanisms by which antimicrobial peptides disrupt bacterial membranes. Using molecular dynamics simulations, it will analyze the interactions of these peptides with lipid bilayers to better understand their effectiveness and toxicity.
Antimicrobial peptides (AMPs) are a promising new class of antibiotics, the mechanism of which usually involves binding to membranes with subsequent disruption.
The disruption process is, however, still poorly understood, mostly because it seems to be mediated by states - pore formation or in-depth AMP insertion - that are unordered and very short-lived.
My PhD work focused on using and developing biophysical methodologies to study the conditions at which the AMP-mediated disruption is triggered…
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