CORDIS Project
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This project investigates the role of caveolae, small invaginations in cell membranes, focusing on the cavin protein family. By employing innovative techniques, it aims to understand how these structures contribute to various physiological processes across different tissues.
Caveolae are small invaginations of the plasma membrane, with characteristic flask-shaped morphology, found in most mammalian cells.
Phenotypes of mice lacking genes for caveolins, key protein components of caveolae, show that these structures are involved in many physiological processes, such as vesicle trafficking, cholesterol homeostasis, signal transduction, tumor suppression and mechanosensing.
However, many proposed physiological roles for caveolae are controversial, making a rigorous anal…
MEDICAL RESEARCH COUNCIL
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