CORDIS Project
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This project explores the mechanisms of muscle regeneration and the role of specific proteins in muscular dystrophy. It aims to identify therapeutic targets to enhance muscle repair and address degenerative muscle conditions.
The objective of this proposal is to define the role of histone deacetylase 4 (HDAC4) and myocyte enhancer factor 2 (MEF2) in muscle regeneration and dystrophy.
In response to injury, skeletal muscle activates orchestrated molecular mechanisms to restore muscle architecture and functionality.
Our preliminary data showed that skeletal muscle from mice lacking HDAC4, an inhibitor of the myogenic factor MEF2, regenerates better than that of control mice following injury. MEF2 activity is triggered…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
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