CORDIS Project
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This study aims to understand how bidirectional signaling systems, specifically Eph/ephrin signaling, regulate synapse formation and activity in vivo. Using zebrafish and mouse models, it examines the effects of Eph receptor clustering on synaptic transmission and stability.
The present study aims to elucidate how bidirectional signaling systems regulate synapse formation and activity, in vivo.
In particular, I will address how repulsive actions of Eph/ephrin signaling during axon pathfinding are overcome and turned into adhesive actions, required for synapse formation and functioning.
Therefore, I will study the effects of either stimulation or inhibition of Eph receptor clustering in two different in vivo models and, in an inducible way.
Live-imaging of Eph recept…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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