CORDIS Project
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This project investigates the trafficking mechanisms of AMPA type glutamate receptors in cerebellar stellate cells, focusing on the differences between calcium-impermeable and calcium-permeable receptors. By using advanced electrophysiology and imaging techniques, it aims to uncover the cellular processes that regulate…
AMPA type glutamate receptors (AMPARs) mediate fast excitatory transmission in the CNS.
These receptors can be calcium-impermeable (CI AMPARs) or calcium permeable (CP AMPARs).
Because insertion or removal of CI AMPARs at synapses is key to the expression of canonical forms of plasticity, such as LTP (long-term potentiation) and LTD (long-term depression), the trafficking of these receptors has been extensively studied.
In various regions of the brain, CP AMPARs have been implicated in important…
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