CORDIS Project
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This project investigates clear cell renal cell carcinoma (ccRCC) by exploring its molecular causes and developing a flexible gene expression manipulation system in mice. The goal is to create models for testing new treatments for this prevalent kidney cancer.
This research grant has two major aspects.
The first seeks to understand the molecular and cellular basis of the evolution of clear cell renal cell carcinoma(ccRCC), the most frequent form of kidney cancer.
We will utilise an integrated approach based on mouse genetics, the use of primary kidney epithelial cell culture systems, genetic screening approaches using RNA interference libraries and analysis of the genetic and molecular changes that arise in human kidney tumours.
The rationale behind t…
University of Zurich
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