CORDIS Project
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This project investigates the molecular mechanisms behind the formation of the mouse blastocyst, focusing on lineage specification during early development. It employs functional screens and gene expression profiling to identify key molecules involved in this process.
Early mammalian development is characterized by formation of the blastocyst, composed of the pluripotent inner cell mass surrounded by a one-cell layer of epithelial cells, the trophectoderm.
Despite its importance for understanding mammalian development and for stem cell research, the mechanism of blastocyst morphogenesis and patterning has long been elusive and a subject of controversy.
The ultimate goal of this project is to understand the molecular mechanism of the lineage establishment in t…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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