CORDIS Project
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This project investigates the dynamics of ionotropic glutamate receptors, which are crucial for neuron communication and synaptic plasticity. By using molecular dynamics simulations and machine learning, it aims to understand how structural differences among these receptors influence their behavior, which is vital for…
Ionotropic Glutamate receptors (iGluRs) influence the timescales at which neurons communicate with each other.
The dynamics and flexibility of the response of iGluRs to neurotransmitter binding give rise to the synaptic plasticity responsible for normal human intelligence.
Dysfunction of the iGluRs is causally responsible for diseases such as Alzheimer's and Amyotrophic lateral sclerosis.
It is therefore medically important to understand how the structure-function relationship in the iGluRs ope…
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