CORDIS Project
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This project focuses on understanding the molecular mechanisms behind immune cell function, particularly how certain proteins regulate the release of cytotoxic granules from natural killer cells. It aims to clarify the signaling pathways involved in this critical immune response.
The study of immunodeficiency syndromes such as familial hemophagocytic lymphohistiocytosis (FHL) and Griscelli Syndrome type 2 (GS2) has revealed a crucial role for Munc13-4, Stx11, Munc18-2 and Rab27a – members of protein families that regulate vesicle trafficking and membrane fusion – in cytotoxic granule exocytosis.
Loss-of-function mutations in these proteins result in loss of target cell killing by NK cells and CD8+ T cells, resulting in a life-threatening sepsis-like condition.
The precis…
KAROLINSKA INSTITUTET
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