CORDIS Project
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This project investigates T cell acute lymphoblastic leukemia (T-ALL) by analyzing genetic mutations that drive the disease. It aims to identify specific oncogenes and therapeutic targets through comprehensive molecular studies and mouse models, ultimately contributing to the development of targeted treatments for this…
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive T cell malignancy that is most common in children and adolescents.
Our current understanding of the molecular genetics of T-ALL indicates that leukemic transformation of thymocytes is caused by the cooperation of mutations that affect proliferation, survival, cell cycle, differentiation and self renewal.
Molecular analysis has identified a large number of T-ALL specific oncogenes, but the genetic defects that are implicated in the aber…
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