CORDIS Project
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This project investigates the role of small RNAs and Argonaute proteins in gene silencing across generations in the nematode Caenorhabditis elegans. It aims to identify the factors involved in the establishment, inheritance, and maintenance of transcriptional silencing, enhancing our understanding of epigenetic inherit…
Small RNAs have a remarkable regulatory role in most eukaryotes.
These molecules bind to Argonaute proteins (AGO) and form a complex that recognizes its mRNA targets by sequence complementarity.
The regulatory role is driven by the catalytic activity of AGO, but not exclusively.
In several organisms, AGO recruits other factors to perform the silencing.
Remarkably, during transcriptional gene silencing, the small RNA-AGO complex engages factors that interfere with transcription but also proteins…
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