CORDIS Project
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This project studies the differentiation of monocytes into intestinal macrophages, aiming to understand their role in gut health and inflammation. It seeks to identify molecular mechanisms that could inform future therapies for inflammatory bowel disorders.
Monocytes are central players in inflammation.
Progress in understanding their differentiation in target tissues bears potential to manipulate their activities for therapeutic purposes.
Here we propose to study the generation of intestinal macrophages (MΦs) as a paradigm, taking advantage of a unique experimental system to elucidate in vivo monocyte fates.The intestine hosts billions of bacteria that assist food uptake, but also pose a challenge, as we have to tolerate these beneficial commensal…
WEIZMANN INSTITUTE OF SCIENCE
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