CORDIS Project
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This project investigates the role of hydroxylation in regulating the hypoxic response in humans. By studying the enzymes involved, it aims to enhance our understanding of oxygen sensing and develop new therapeutic strategies for conditions like ischemic disease and cancer.
The hypoxic response in humans is regulated by enzymes that catalyse the post-translational hydroxylation of hypoxia inducible factor (HIF).
Prolyl-hydroxylation signals for HIF-alpha degradation whilst asparaginyl-hydroxylation blocks the transcriptional activity of HIF.
The absolute requirement of the HIF hydroxylases for oxygen enables them to act as hypoxia sensors.
The overall goal of the proposed programme is to capitalize on recent advances in this field arising from the joint Schofield a…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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