CORDIS Project
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This project explores how the small GTPase Epac2 regulates the structure and function of dendritic spines, which are crucial for learning and memory. It aims to understand the molecular mechanisms behind synaptic changes in the brain and their implications for autism-related disorders.
Long-term synaptic plasticity is believed to underlie learning and memory and also the tuning of neural circuitry during development.
Plasticity of excitatory synapses involves both changes in the function and morphology of dendritic spines, small actin-rich, dynamic protrusions that are the sites of excitatory neurotransmission.
The coordination of the structure and function of dendritic spines is essential for proper cognitive function, however the molecular mechanisms that link these proces…
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