CORDIS Project
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This project investigates how viruses modify their RNA to evade the host's immune system. It focuses on the hepatitis C virus and its unique use of flavin adenine dinucleotide for RNA protection, aiming to uncover new antiviral targets and enhance understanding of viral replication mechanisms.
Viruses cause significant disease, exemplified by the COVID-19 pandemic.
Most studies of virus-host interactions focused on proteins, however, RNA holds great promise for basic and therapeutic exploration.
Viruses evolved elaborate strategies for RNA protection, including 5’ capping and internal modification.
The goal of this proposal is to discover and characterize viral RNA modifications installed by viral enzymes, including their role in innate immune evasion.
This could uncover novel RNA-bas…
KOBENHAVNS UNIVERSITET
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