CORDIS Project
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This project aims to understand how normal cell differentiation is disrupted in early cancer development using a mouse model. By manipulating ion channels in gastric stem cells, the research seeks to uncover the relationship between membrane potential and cancer stem cell behavior, potentially identifying new cancer tr…
The studies proposed in the current application seek to answer a critical question hindering progress in the early detection and treatment of cancer:
How is normal differentiation and lineage commitment disrupted in the earliest stages of cancer development?
As a first step to answer this question we have generated a multi-organ mouse cancer and lineage tracing model by recombining conditional oncogene, tumour suppressor gene and lineage tracing alleles in cells expressing Cre-recombinase from…
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