CORDIS Project
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The project investigates how nascent proteins emerging from ribosomes influence the degradation of their corresponding mRNAs, using tubulin autoregulation as a model. It aims to identify factors involved in this process and understand their mechanisms, contributing to the broader understanding of gene expression regula…
Cell tightly regulate mRNA processing, localisation and stability to ensure accurate gene expression in diverse cellular states and conditions.
Most of these mRNA regulation steps have traditionally been thought to primarily happen before translation.
However, recent discoveries highlight the role of nascent polypeptides on translating ribosomes in the active regulation of mRNAs.
As the nascent protein emerges from the ribosome, it marks the identity of the encoding mRNA by its unique amino acid…
UNITED KINGDOM RESEARCH AND INNOVATION
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