CORDIS Project
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This project investigates the role of Eif4E-binding proteins in protein synthesis within heart cells, particularly how they affect cardiac function in both healthy and diseased states. It aims to understand the molecular mechanisms behind heart failure by identifying specific mRNAs regulated by these proteins.
Protein synthesis is among the principal biological processes underlying cardiac hypertrophy, an early event in many forms of heart failure (HF).
It is associated with worsening of cardiac function after long-term exposure to noxae.
The rate-limiting step of protein synthesis is mRNA translation, which is controlled by factors involved in initiation and/or elongation. 4E-BPs regulate the translation of a subset of mRNAs by competing with eIF4G for binding to eIF4E, preventing the assembly of eIF…
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