CORDIS Project
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This project focuses on understanding the molecular mechanisms of gene regulation in fruit flies, particularly how males compensate for gene loss on their single sex chromosome. The research aims to elucidate the structure of a key protein complex involved in this process.
Metazoa evolved homogametic and heterogametic sexes.
In heterogametic sexes one of the two sex chromosomes underwent loss of essential genes and molecular mechanisms evolved to compensate for this loss.In fruit flies, males up-regulate the transcription levels of many genes on the only sex chromosome by 2-fold.
This effect is associated with acetylation of H4K16 mediated by MOF, the catalytic subunit of the Dosage Compensation Complex (DCC).
The DCC can be narrowed down to the MSL1-MSL3-MOF comp…
MEDICAL RESEARCH COUNCIL
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