CORDIS Project
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This project seeks to develop new therapies for Amyotrophic Lateral Sclerosis by designing small molecules that modulate neuroinflammation and oxidative stress. By targeting specific pathways, the project aims to enhance motor neuron survival and ultimately improve patient outcomes.
Amyotrophic Lateral Sclerosis is a severe neurodegenerative disease characterized by the degeneration of the upper and lower motor neurons (MN), ultimately leading to patient death by respiratory failure.
Despite being the most common adult-onset motor neuron disease, the drugs available till now are symptomatic and only extend patients life expectancy a few months without changing the onset of the disease.
Recent studies revealed that NF-κB transcription factor is the major regulator of neuroin…
UNIVERSIDADE DO PORTO
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