CORDIS Project
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This project investigates the mechanisms of transcriptional proofreading in various RNA polymerases across different life forms. It aims to understand how these enzymes correct errors during the transcription of DNA into RNA, which is crucial for cellular function and could inform drug design against bacterial and fung…
Transcription, the copying of DNA into RNA, is the first step in the realisation of genetic information. RNA is either directly used by the cell or decoded into proteins during translation.
The accuracy of transcription is thus essential for proper functioning of the cell.
In all living organisms transcription is performed by multisubunit RNA polymerases, enzymes that are highly conserved in evolution from bacteria to humans.
Surprisingly, the mechanisms that ensure accuracy of transcription rem…
UNIVERSITY OF NEWCASTLE UPON TYNE
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