CORDIS Project
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This project investigates the role of sinonasal mucosal breaks in ANCA-associated vasculitis, an autoimmune disease. By analyzing B-cell responses and the sinonasal microbiome, it aims to uncover mechanisms triggering the disease and explore new therapeutic strategies to prevent relapses.
ANCA-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by inflammation of the small blood vessels. ANCAs, autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO), play a central role in the pathogenesis.
They induce excessive activation of neutrophils, resulting in necrotizing injury of small vessels.
The loss of tolerance in AAV is thought to be the result of genetic, environmental, and ageing factors.
Although infectious triggers are implicated, thei…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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United States, Stanford
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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