CORDIS Project
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This project investigates the relationship between Type-2 Diabetes and bone fragility, focusing on how changes in bone matrix properties affect fracture risk. It aims to develop a new framework for assessing bone quality and fracture probability using measurable biomarkers.
Type-2 (T2) Diabetes is associated with a 3-fold increase in bone fracture risk, despite the fact that bone volume is not reduced.
This implies that T2 diabetes impairs bone quality, whereby the intrinsic material properties of the bone matrix are altered.
However, current diagnostic techniques are unable to predict fracture probability in T2 diabetes as they are based on measures of bone quantity.
While it is believed that non-enzymatic cross-linking of organic proteins (also known as AGE accum…
UNIVERSITY OF GALWAY
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