CORDIS Project
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The project focuses on understanding how gene expression is regulated in multicellular plants by combining single-cell genomics, explainable artificial intelligence, and synthetic promoter engineering. It aims to predict and validate regulatory sequences that control gene expression, particularly under stress condition…
Multicellular plants control the fine-grained expression of thousands of genes during growth, development, and in response to external stimuli.
While gene expression varies strongly between different organs and tissues, how this specificity is encoded in the genome is largely unknown.
Although various regulatory DNA sequences and sequence-specific transcription factors controlling diverse transcriptional responses have been described, the combinatorial nature of the regulatory code makes the app…
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