CORDIS Project
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The project aims to explore the role of intrinsically disordered proteins in clathrin-mediated endocytosis. By using advanced imaging techniques, it seeks to understand how linear motifs within these proteins facilitate critical biological interactions.
Linear motifs are short sequence stretches that occur in intrinsically disordered protein regions (IDRs) lacking stable secondary and tertiary structure, and mediate vital interactions within various biological systems.
An exemplary system for the presence of IDRs and a high concentration of linear motifs is the clathrin mediated endocytosis machinery of the eukaryotic cell, where a complex interaction network of IDR-rich adaptor proteins enables both protein and lipid interactions.
The molecula…
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