CORDIS Project
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This project investigates the role of epigenetic mutations in pancreatic cancer, focusing on how changes in chromatin affect gene expression. Using advanced technologies, it aims to uncover mechanisms of gene deregulation to inform new cancer treatment strategies.
Chromatin, the complex structured macromolecule consisting of DNA wrapped around histones, represents the ground where transcription factors, signalling pathways and mechanical stimulations converge to regulate gene expression and determine cellular phenotypes.
Epigenetic mechanisms altering these phenotypes without modifying the DNA sequence are extremely pliable and allow for subtle and reversible changes in gene regulation.
Consequently, aberrations in chromatin regulation are associated with…
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