CORDIS Project
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This project focuses on developing new methods for synthesizing diverse small molecules that mimic natural products, which are crucial for biological research. It aims to create a library of alkaloid-like compounds for use in cell and protein assays.
Chemical Genetics research programmes require libraries of small molecules which span large tracts of biologically-relevant chemical space.
Natural products necessarily reside in such chemical space, since they bind both biosynthetic enzymes and target macromolecules.
However, natural product partners are not available for most protein targets.
Chemical Genetics has spawned diversity-oriented synthesis (DOS), in which libraries of diverse molecules are assembled in up to ca. five steps.
The…
UNIVERSITY OF LEEDS
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