CORDIS Project
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This project investigates the unconventional secretion of proteins that lack a signal sequence for entry into the Endoplasmic Reticulum. It focuses on the mechanisms by which certain proteins, such as Acb1, are secreted via autophagosomes in yeast, aiming to clarify their roles in various biological processes and disea…
Approximately 30% of the human genes encode proteins that enter the Endoplasmic Reticulum (ER) by a hydrophobic sequence called the signal sequence.
Most of these proteins are transported to the Golgi apparatus for sorting and subsequent delivery to the endosomes, cell surface, and the extracellular space.
There is good understanding of this process of ¿conventional¿ protein secretion.
Surprisingly, there is another class of cytoplasmic proteins that are secreted even though they a lack signal s…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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