CORDIS Project
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This project investigates how skeletal muscles influence T cell function and combat T cell exhaustion during chronic infections. It explores the role of metabolites and myokines in restoring antiviral T cell responses and examines the potential of increasing muscle mass as a therapeutic strategy to enhance immune respo…
Although skeletal muscles are not traditionally considered to be constituents of the immune system, the loss of skeletal muscle mass in chronic infection is frequently associated with impaired T cell function, or T cell exhaustion.
Whether and how muscles regulate T cell exhaustion is unknown.
We found that skeletal muscles antagonized T cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus (LCMV) clone 13.
Spleen-derived exhausted CD8+ skeletal muscle-infiltrating…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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