CORDIS Project
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This project investigates how estrogen-related receptors, particularly ERRγ, influence the activation and recruitment of muscle stem cells for tissue repair. By understanding these mechanisms, the project aims to enhance muscle regeneration following injury or degeneration, potentially leading to new therapeutic strate…
Skeletal muscle is a highly plastic tissue capable of spontaneous repair in response to injury via the recruitment of muscle stem cells called the satellite cells.
These cells are localised within the myofibre basal lamina and are activated upon muscle damage, they proliferate and differentiate to replace the damaged muscle.
Satellite cells are the key rate-limiting step for successful repair and the transcriptional cues that emanate from the skeletal muscle to activate regeneration are unclear.…
UNIVERSITY OF HULL
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