CORDIS Project
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This project examines the relationship between cancer mutations and immune responses in patients. It aims to validate hypotheses regarding how mutations influence T cell recognition and the implications for future cancer therapies, including targeted treatments and immunotherapy.
It is well documented that each human cancer has acquired a large number of mutations (50-500), some of which are drivers for tumorigenicity, others of which are indolent passengers.
It has also been established that such mutations can be recognized by the patient´s T cells via the presentation of mutated peptides on HLA molecules of a tumor cell.
If such immune responses against cancer mutations are generally relevant for cancer development (according to Paul Ehrlich´s hypothesis), one can pred…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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