CORDIS Project
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This project investigates how somatic mutations in stem and progenitor cells affect tissue integrity and regenerative potential. By analyzing human tissues and mouse models, it aims to understand the balance between mutant cell expansion and tissue health, potentially revealing new insights into aging and disease.
Healthy tissues become progressively populated of clonally expanded cells that have acquired somatic mutations.
Often these mutations modify cancer genes promoting cell plasticity, self-renewal, and growth, all features known to decline with ageing.
Despite being pervasive across tissues and persistent throughout life, only rarely mutant cells become pathogenic.
Here we hypothesise that somatic mutations enhance tissue integrity by increasing the fitness of stem/progenitor cells (SPCs) to counte…
THE FRANCIS CRICK INSTITUTE LIMITED
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United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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