CORDIS Project
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This project investigates the link between gut bacteria and early-onset colorectal cancer by studying how specific bacterial genotoxins, like colibactin, induce mutations in human intestinal organoids. The goal is to understand the mechanisms behind these mutations and their role in cancer development, ultimately aidin…
The increasing incidence of early-onset colorectal cancer (EO-CRC) points to an unknown, possibly preventable, cause. A strong candidate is the gut microbiome.
Experimental studies show certain bacterial strains can affect CRC onset, potentially by producing genotoxins that induce cancer-driving mutations.
Our project aims to test this hypothesis.
We have identified colibactin, a genotoxin produced by certain E. coli strains, which leaves a specific mutation pattern (SBS88) found in both healthy…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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