CORDIS Project
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This research aims to explore how genetic mutations interact to influence traits and diseases. By using deep mutagenesis, the project seeks to develop methods for determining protein structures and understanding mutation effects on cellular functions.
The goal of my research is to understand mutations and how they interact to alter phenotypes and disease.
We recently initiated a new research direction that uses systematic (‘deep’) mutagenesis to quantify, understand, and predict how diverse mutations interact non-additively within and between molecules to affect phenotypes at multiple scales.
Very excitingly, we have also shown that quantifying genetic interactions by deep mutagenesis provides sufficient information to determine the 3D struct…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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